![]() Retinol esters are often used to lower the irritation potential and increase stability, but a tradeoff is decreased retinoid activity and benefits. Retinol (vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. ![]() These derivatives are metabolized to the active form by skin cells. In recent years, milder synthetic and natural derivatives have become popular alternatives to retinoic acid. Retinoic acid is a topically applied ingredient recognized for its anti-ageing benefits however, it can be irritating to skin and is sold as a prescription medication. Vitamin A Chemistry ChallengesĪlthough the benefits of retinoids have been known for decades, skin irritation, photochemical instability, and toxicity concerns have hindered their use. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. The novel retinoid is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. The effectiveness of the novel retinoid at filling lines and wrinkles can be seen in Figure 1. These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. Moreover, the novel retinoid stimulates skin cell proliferation restoring thickness to skin that has become thinner over time. Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity and hydration to provide a radiant and fresh appearance. As humans age, skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. Stimulating cell proliferation and cell turnover are important for normalizing cell renewal and repair processes. Stimulating these age-defying processes in the skin is critical for fighting and reversing signs of aging. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit the skin complexion are switched on. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. This skin care active ingredient belongs to a class of chemical compounds called retinoids, which are natural and synthetic derivatives of vitamin A, capable of binding to retinoid receptors. To reflect the policies of the shipping companies we use, all weights will be rounded up to the next full pound.Granactive Retinoid (INCI Name: Dimethyl Isosorbide (and) Hydroxypinacolone Retinoate), is a cosmetic grade ester of all-trans retinoic acid. The weight of any such item can be found on its detail page. Please also note that the shipping rates for many items we sell are weight-based. Depending on the shipping provider you choose, shipping date estimates may appear on the shipping quotes page. When you place an order, we will estimate shipping and delivery dates for you based on the availability of your items and the shipping options you choose. Note that there are restrictions on some products, and some products cannot be shipped to international destinations. ![]() We can ship to virtually any address in the world. We'll notify you via e-mail of your refund once we've received and processed the returned item. If you need to return an item, simply login to your account, view the order using the "Complete Orders" link under the My Account menu and click the Return Item(s) button. This time period includes the transit time for us to receive your return from the shipper (3 to 5 business days), the time it takes us to process your return once we receive it (2 to 4 business days), and the time it takes your bank to process our refund request (5 to 10 business days). You should expect to receive your refund within 10 days of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. We'll also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.). You may return most new, unopened items within 30 days of delivery for a full refund.
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